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The recommended first line of uratelowering therapy includes the xanthine oxidase inhibitors allopurinol and febuxostat by reducing urate

The biochemistry is real

By binding to GLP-1 receptors, these medications enhance glucose-dependent insulin secretion from pancreatic beta cells, suppress inappropriate glucagon release, slow gastric emptying, and promote satiety through central nervous system pathways

JAMA Psychiatry 76:924

Weight gain while taking Wegovy can happen when calorie intake remains higher than energy burned, the body has not reached the therapeutic dose, or temporary water retention occurs

In 2026, retatrutide stays investigational and is not an approved retail medicine