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Importantly, RRM2 is often found overexpressed in NB, and its depletion was shown to induce G1/S phase arrest due to replicative stress and checkpoint kinase 1 (CHK1) activation (47, 48)

The injection includes a combination of anesthetic (lidocaine or bupivacaine) and steroid (cortisone, Kenalog or dexamethasone)

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Recombinant thrombomodulin attenuates hyper-inflammation and glycocalyx damage in a murine model of Streptococcus pneumoniae -induced sepsis