| Take home message A study presented at the European Congress on Obesity showed that semaglutide (Ozempic/Wegovy) could reduce the number of major cardiovascular events (MACE), like a heart attack or stroke, by 20% compared to placebo (participants not taking the medication)
10.1124/mol.105.019240
The dose and timelines stated below are suggested by the manufacturers of Ozempic and Wegovy If you have diabetes and you take Ozempic, the doses are 25 mg once-weekly for first 4 weeks 5 mg once-weekly for at least 4 weeks 1 mg once-weekly for at least 4 weeks if your doctor feels you need to manage your blood glucose 2 mg once-weekly if your doctor feels it is necessary for better blood glucose management
Endocrine feedback : Chronic exposure to hexarelin may lead to desensitization or downregulation of receptor sensitivity
Upon direct intramuscular injection of pre-formed -synuclein fibrils in the duodenum of ASO mice, investigators report a heightened inflammatory response (IL-6) in the duodenum 7 days post-inoculation (dpi), which likely suggests an early protective response to maintain enteric health (Schafer et al., 1999
Notably, 31% of patients on GLP-1 RAs became completely headache-free at 6 months, versus only 8% of those on usual care (this difference did not remain significant after adjusting for weight loss)
