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The initial identification of ChaC-like enzymes in plants occurred in a 2005 study on submergence-induced genes in rice, where the upregulated gene OsCTP was noted for its high similarity to the E

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demonstrated in mice that chronic inflammation, induced by the knockout of the nfkb1 subunit of the NF-B transcription factor, exacerbates telomere dysfunction and cell senescence through a feedback loop involving NF-B, COX-2, and ROS, thereby leading to premature aging and reduced tissue regeneration in liver and gut (Jurk et al., 2014)

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